New studies of the excitatory sodium currents in heart muscle.

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New studies of the excitatory sodium currents in heart muscle.

After decades of frustration with inadequate methods, cardiac electrophysiologists have developed new techniques for superior control of membrane potential by use of single cells, and they have begun careful study of cardiac Na+ currents. Direct recordings of the behavior of single Na+ channels have been made by the newly developed patch clamp technique. Biochemists have made excellent progress...

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Background: Ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. The mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. We aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...

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effects of ketamine on neuronal spontaneous excitatory postsynaptic currents and miniature excitatory postsynaptic currents in the somatosensory cortex of rats

background: ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. the mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. we aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...

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Cardiac sodium and calcium channels: a history of excitatory currents.

The entire concept of ion channels as molecular machines to gate ion traffic across the membrane has only recently been generally recognized, even though ion channels are found in almost all cells. Na+ and Ca2+ channels are the basis of excitability, and in the heart they generate the rhythm, coordinating and controlling cardiac contraction. Dysfunction of ion channels results in arrhythmias th...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1985

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.56.4.475